A truly uncooperative cat has four paws to fend off your intention to give it a pill. Rather than trying to force the kitty to behave, try wrapping the patient in a towel, effectively rendering its claws ineffective.
Towel Wrapping The Difficult-To-Handle Cat
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“Cats do not have to be shown how to have a good time, for they are unfailing ingenious in that respect.”
*James Mason (British Actor, North by Northwest, A Star Is Born)