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PandEcats

The Premier Online Magazine
devoted to Persian & Exotic Shorthair Cats

Search
Close this search box.

PandEcats

The Premier Online Magazine devoted
to Persian & Exotic Shorthair Cats

Search
Close this search box.

DNA Test For Polycystic Kidney Disease (PKD) In Cats

Feline polycystic kidney disease (PKD1) is a heritable form of kidney disease commonly seen in Persians and in cats with Persian ancestry. Affected cats develop cysts on their kidneys. The cysts are present early, often visualized on ultrasound before 12 months of age. Early onset, bilateral presentation (both kidneys), and multiple cysts are all traits of PKD1.  Renal failure usually occurs at a later age.

The symptoms of a cat with PKD1 are similar to those of renal failure. 

Inheritance of PKD1

The mode of Inheritance of PKD1 is autosomal dominant, meaning a single allele of the gene causes the disease. Upon testing, each allele of the gene will be reported as either:

  • N= Normal/Unaffected
  • P= Polycystic kidney disease (PKD1)

DNA Test Results

  • Cats with N/N genoytpe:
    • Do not have this heritable form of polycystic kidney disease.
    • Will not transmit this PKD1 variant to their offspring.
  • Cats with N/P genotype:
    • Will be affected by this heritable form of polycystic kidney disease.
    • Severity of symptoms cannot be predicted. 
    • They will transmit this PKD1 variant to 50% of their offspring.
    • Half the offspring will inherit this polycystic kidney disease.
  • Cats with P/P genotype:
    • Suspected to be lethal and therefore are affected kittens are unlikely to be born and/or survive.

Breeds At Risk

The current DNA test for PKD1 is appropriate for testing Persians and related breeds that at some point in their history used the Persians as an outcross. These related breeds include:

  • British Longhair
  • British Shorthair
  • Burmilla
  • Domestic Shorthair
  • Exotic Longhair
  • Exotic Shorthair
  • Foldex
  • Highland Fold
  • Highland Straight
  • Himalayan
  • Maine Coon
  • Napoleon
  • Ragamuffin
  • Ragdoll
  • Scottish Fold
  • Scottish Straight
  • Selkirk Rex
  • Devon Rex
  • Siberian

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“The mathematical probability of a common cat doing exactly as it pleases is the one scientific absolute in the world.”
*Author Lynn M. Osband

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